The Product

The DNAlyse Panel

One cheek swab, four areas of insight, over 400 reports — for medical professionals, researchers and institutional clients.

Area 01

Predisposition to common disease

Quantified risk across multifactorial conditions where the genetic contribution is well characterised. Reported as risk relative to a reference population, with the contributing variants listed so the result can be interrogated rather than merely read.

Cardiovascular

  • Abdominal aortic aneurysm
  • Angina pectoris
  • Arterial hypertension
  • Atrial fibrillation
  • Coronary heart disease
  • Deep vein thrombosis
  • Heart failure
  • Intracranial aneurysm
  • Myocardial infarction
  • Peripheral arterial disease

Respiratory

  • Asthma
  • Chronic obstructive pulmonary disease (COPD)
  • Allergic rhinitis
  • Nasal polyps

Autoimmune

  • Addison's disease
  • Graves' disease
  • Juvenile idiopathic arthritis
  • Multiple sclerosis
  • Primary biliary cirrhosis
  • Rheumatoid arthritis
  • Systemic lupus erythematosus
  • Type 1 diabetes mellitus
  • Vitiligo

Neurological and psychiatric

  • Alzheimer's disease
  • Amyotrophic lateral sclerosis (ALS)
  • Bipolar disorder
  • Depression
  • Migraine
  • Multiple sclerosis
  • Narcolepsy
  • Parkinson's disease
  • Schizophrenia
  • Restless legs syndrome
  • Sensorineural hearing loss

Gastrointestinal and hepatic

  • Abdominal hernia
  • Barrett's esophagus
  • Chronic kidney disease
  • Crohn's disease
  • Diaphragmatic hernia
  • Diverticulosis / diverticulitis
  • Gallstones
  • Gastroesophageal reflux disease (GERD)
  • Haemorrhoidal disease
  • Non-alcoholic fatty liver disease (NAFLD)
  • Ulcerative colitis
  • Urolithiasis

Oncological

  • Basal cell carcinoma
  • Chronic lymphocytic leukemia
  • Colorectal cancer
  • Cutaneous malignant melanoma
  • Glioblastoma
  • Glioma
  • Lung cancer
  • Multiple myeloma
  • Myeloproliferative neoplasms
  • Neuroblastoma
  • Non-medullary thyroid cancer
  • Oral cavity and oropharyngeal cancer
  • Pancreatic cancer
  • Prostate cancer
  • Squamous cell carcinoma of the skin
  • Testicular germ cell cancer

Endocrine and metabolic

  • Type 2 diabetes mellitus
  • Hyperlipidemia
  • Hypothyroidism
  • Non-toxic multinodular goiter
  • Osteoporosis
  • Non-alcoholic fatty liver disease (NAFLD)

Musculoskeletal

  • Carpal tunnel syndrome
  • Dupuytren's disease
  • Fasciitis
  • General osteoarthritis
  • Osteoarthritis of the hip
  • Osteoarthritis of the knee
  • Gout
  • Juvenile idiopathic arthritis

Dermatological

  • Atopic dermatitis
  • Psoriasis
  • Vitiligo
  • Cutaneous malignant melanoma
  • Basal cell carcinoma
  • Squamous cell carcinoma of the skin

Ophthalmological

  • Age-related macular degeneration
  • Cataracts
  • Keratoconus
  • Macular telangiectasia type 2
  • Open angle glaucoma

Urological

  • Benign prostatic hyperplasia
  • Prostate cancer
  • Urolithiasis

Other conditions

  • Chronic kidney disease
  • Headaches
  • Restless legs syndrome
  • Testicular germ cell cancer
Area 02

Inherited conditions and carrier status

Monogenic conditions across recessive and dominant inheritance patterns. Carrier findings are reported as carrier status without implication of phenotype — relevant to reproductive counselling and to family-history work.

Chromosomal and genetic syndromes

  • Agenesis of the corpus callosum with peripheral neuropathy (ACCPN)
  • Bloom syndrome
  • Cowden syndrome
  • Ehlers-Danlos syndrome (EDS)
  • Familial adenomatous polyposis
  • Li-Fraumeni syndrome
  • Lynch syndrome
  • Neurofibromatosis type I
  • Peters plus syndrome

Metabolic disorders

  • Alpha-1 antitrypsin deficiency
  • Biotinidase deficiency
  • cblA type methylmalonic aciduria
  • cblB type methylmalonic aciduria
  • Classical homocystinuria due to CBS deficiency
  • Congenital disorder of glycosylation type 1a (PMM2-CDG)
  • Dihydrolipoamide dehydrogenase deficiency
  • Dubin-Johnson syndrome
  • Familial hypercholesterolemia
  • Familial hyperinsulinism (ABCC8-related)
  • Fanconi anemia (FANCC-related)
  • Gaucher disease
  • Glutaric acidemia type 1
  • Glutaric acidemia type 2
  • Glycogen storage disease type 1A (Von Gierke disease)
  • Glycogen storage disease type 1B
  • Glycogen storage disease type 3
  • Glycogen storage disease type 5
  • Glycogenosis type 2 (Pompe disease)
  • Hereditary fructose intolerance
  • Homocystinuria due to MTHFR deficiency
  • Medium-chain acyl-CoA dehydrogenase deficiency (MCADD)
  • Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
  • Mucolipidosis IV
  • Mucolipidosis type II
  • Niemann-Pick disease type A
  • Phenylketonuria
  • Primary hyperoxaluria type 1 (PH1)
  • Primary hyperoxaluria type 2 (PH2)
  • Pyruvate kinase deficiency
  • Refsum disease
  • Salla disease
  • Short-chain acyl-CoA dehydrogenase deficiency (SCADD)
  • Sjögren-Larsson syndrome
  • Tay-Sachs disease
  • Tyrosinemia type I
  • Wilson disease
  • Zellweger syndrome

Blood disorders

  • Beta thalassemia
  • Hemophilia A
  • von Willebrand disease

Neurodevelopmental disorders

  • ARSACS (autosomal recessive spastic ataxia of Charlevoix-Saguenay)
  • Canavan disease
  • Congenital muscular alpha-dystroglycanopathy and Walker-Warburg syndrome
  • Congenital myasthenic syndrome
  • Familial dysautonomia (Riley-Day syndrome)
  • Leigh syndrome, French-Canadian type (LSFC)
  • Leukoencephalopathy with vanishing white matter
  • Neuronal ceroid lipofuscinosis type 1 (PPT1)
  • Neuronal ceroid lipofuscinosis type 3 (CLN3)
  • Neuronal ceroid lipofuscinosis type 5 (CLN5)
  • Neuronal ceroid lipofuscinosis type 6 (CLN6)
  • Neuronal ceroid lipofuscinosis type 7 (MFSD8)
  • Pontocerebellar hypoplasia

Muscle and movement disorders

  • Congenital stationary night blindness 1C
  • Hypokalemic periodic paralysis
  • Limb-girdle muscular dystrophy

Cardiovascular disorders

  • Brugada syndrome
  • Dilated cardiomyopathy 1A
  • Familial hypertrophic cardiomyopathy (HCM)
  • Familial transthyretin amyloidosis
  • Malignant hyperthermia

Metabolic bone diseases

  • Hypophosphatasia
  • GRACILE syndrome
  • Maple syrup urine disease type 1B
  • Very long chain acyl-CoA dehydrogenase deficiency (VLCADD)

Visual disorders

  • Complete achromatopsia (type 2) and incomplete achromatopsia
  • Retinitis pigmentosa
  • Type 1 oculocutaneous albinism (tyrosinase negative)
  • Type 2 oculocutaneous albinism (tyrosinase positive)

Hearing disorders

  • Non-syndromic mitochondrial hearing loss
  • Non-syndromic hearing loss and deafness, DFNB1
  • Usher syndrome

Cystic and polycystic conditions

  • Autosomal recessive polycystic kidney disease
  • Birt-Hogg-Dubé syndrome
  • Cystic fibrosis
  • Cystinosis

Dermatological conditions

  • Junctional epidermolysis bullosa
  • Rhizomelic chondrodysplasia punctata type 1

Other specific disorders

  • Acute intermittent porphyria
  • Pyridoxine-dependent epilepsy
  • Familial advanced sleep phase syndrome (FASPS)
  • Multiple endocrine neoplasia 2B
Area 03

Pharmacogenomics

Metabolism and response profiles across commonly prescribed classes, reported against established guideline categories so findings map onto prescribing frameworks clinicians already use.

Pharmacogenomic results inform prescribing decisions; they do not replace them. No patient should start, stop, or alter the dose of any medication on the basis of this report without consulting their prescribing physician.

Dosage guidance

Analgesics and anti-inflammatories

  • Celecoxib
  • Ibuprofen

Anticoagulants and immunomodulators

  • Clopidogrel
  • Warfarin
  • Acenocoumarol, phenprocoumon
  • Tacrolimus

Anticonvulsants

  • Phenytoin
  • Brivaracetam
  • Carbamazepine
  • Clobazam
  • Valproic acid

Antidepressants

  • Amitriptyline
  • Citalopram
  • Clomipramine
  • Desipramine
  • Doxepin
  • Escitalopram
  • Fluoxetine
  • Fluvoxamine
  • Imipramine
  • Nortriptyline
  • Paroxetine
  • Trimipramine
  • Venlafaxine
  • Vortioxetine

Antipsychotics

  • Aripiprazole
  • Brexpiprazole
  • Haloperidol
  • Iloperidone
  • Olanzapine
  • Pimozide
  • Quetiapine
  • Risperidone
  • Zuclopenthixol

Anxiolytics and sedatives

  • Diazepam

Beta blockers

  • Metoprolol

Statins and lipid-lowering

  • Atorvastatin
  • Fluvastatin
  • Lovastatin
  • Pitavastatin
  • Pravastatin
  • Rosuvastatin
  • Simvastatin
  • Statins — dosage and risk of myopathy

Proton-pump inhibitors

  • Lansoprazole, dexlansoprazole
  • Omeprazole
  • Pantoprazole

Immunosuppressants

  • Methotrexate (in rheumatoid arthritis)
  • Thioguanine, azathioprine, mercaptopurine

Other agents

  • Amifampridine
  • Atomoxetine
  • Codeine
  • Flecainide
  • Folic acid
  • Tramadol
  • Voriconazole

Adverse reaction risk

Antibiotics

  • Aminoglycoside antibiotics
  • Flucloxacillin

Antidepressants

  • Amitriptyline
  • Citalopram
  • Clomipramine
  • Desipramine
  • Doxepin
  • Escitalopram
  • Fluoxetine
  • Fluvoxamine
  • Imipramine
  • Nortriptyline
  • Paroxetine
  • Sertraline
  • Trimipramine
  • Venlafaxine
  • Vortioxetine

Anticoagulants

  • Warfarin
  • Acenocoumarol, phenprocoumon

Antipsychotics

  • Olanzapine
  • Aripiprazole

Antiretrovirals

  • Efavirenz
  • Atazanavir
  • Abacavir

Antineoplastics

  • Docetaxel
  • Methotrexate
  • Irinotecan

Anti-epileptics

  • Valproic acid
  • Phenytoin
  • Clobazam

Other agents

  • G6PD deficiency and adverse drug reactions
  • Isoniazid
  • Methotrexate
  • Inhalational anaesthetics and succinylcholine
  • Peginterferon alfa-2a / alfa-2b and ribavirin
  • Lumacaftor + ivacaftor

Expected efficacy

Cystic fibrosis modulators

  • Ivacaftor
  • Lumacaftor + ivacaftor

Analgesics and anti-inflammatories

  • Celecoxib
  • Ibuprofen

Anticoagulants

  • Clopidogrel

Antipsychotics

  • Olanzapine
  • Aripiprazole

Anxiolytics and sedatives

  • Diazepam

Antiretrovirals

  • Efavirenz

Statins and lipid-lowering

  • Atorvastatin
  • Fluvastatin
  • Lovastatin
  • Pitavastatin
  • Pravastatin
  • Rosuvastatin
  • Simvastatin
  • Statins — dosage and risk of myopathy

Immunosuppressants

  • Methotrexate (in rheumatoid arthritis)
  • Thioguanine, azathioprine, mercaptopurine

Other agents

  • Amifampridine
  • Atomoxetine
  • Codeine
  • Flecainide
  • Tramadol
  • Voriconazole
Area 04

Traits, wellness and ancestry

Nutrient and micronutrient metabolism, caffeine and alcohol processing, physical and sensory traits, and biogeographical ancestry with maternal and paternal lineage assignment.

Nutrition and metabolism

Vitamin and nutrient levels

  • Vitamin A (beta carotene) levels
  • Vitamin B12 levels
  • Vitamin C levels
  • Vitamin D levels
  • Vitamin E levels
  • Long-chain omega fatty acid levels
  • Glycated hemoglobin levels

Food intolerances

  • Lactose intolerance
  • Histamine intolerance
  • Celiac disease predisposition
  • Genetic predisposition to peanut allergy

Taste and food preference

  • Bitter taste perception
  • Preference for sweets
  • Food intake control
  • Farmer-hunter profile

Metabolism and body composition

  • Basal metabolic rate
  • Body mass index
  • Blood glucose
  • Prediction of visceral adipose tissue
  • Heat production in response to cold

Caffeine and alcohol

  • Caffeine and sports performance
  • Caffeine dependence after prolonged consumption
  • Caffeine and anxiety
  • Alcohol dependence after prolonged consumption
  • Nicotine dependence after prolonged consumption

Metabolizer profiles

  • CYP2C19 metabolizer profile
  • CYP2C9 metabolizer profile
  • CYP2D6 metabolizer profile
  • CYP3A5 metabolizer profile

Physiology and wellness

Blood pressure and cholesterol

  • Systolic blood pressure levels
  • Diastolic blood pressure levels
  • HDL cholesterol levels
  • LDL cholesterol levels

Muscle and tendon

  • Exercise-induced muscle damage (initial phase)
  • Exercise-induced muscle damage (second phase)
  • Exercise-induced muscle damage (regeneration capacity)
  • Muscle endurance
  • Tendinopathies in the lower extremities
  • Tendinopathies in the upper extremities
  • Myoadenylate deaminase (AMPD1 gene)

Sleep and circadian rhythm

  • Morning circadian rhythm (morning person)
  • Sleep duration
  • Insomnia
  • Probability of snoring

Hormonal and endocrine markers

  • Sex hormone regulation (SHBG)
  • Thyroid function (TSH levels)
  • Prostate specific antigen (PSA) levels

Bone and respiratory function

  • Bone mineral density
  • Lung function (exhaled air volume)
  • Antioxidant capacity
  • Intraocular pressure

Blood and immunity markers

  • ABO/Rh blood group
  • CCR5-delta32 and susceptibility to HIV infection
  • Duffy antigen and malaria resistance
  • HLA-B27 antigen
  • C-reactive protein levels
  • Blood coagulation, factor V Leiden and 20210G-A
  • Persistence of fetal hemoglobin
  • Secretor status and ABH antigens (FUT2 gene)

Oral and dental

  • Permanent tooth eruption
  • Dental caries and periodontitis
  • Mouth ulcers

Individual gene variants

  • COMT gene
  • MTHFR gene
  • MTR gene
  • MTRR gene
  • QT interval
  • Epigenetic aging

Physical and sensory traits

Hair

  • Hair colour
  • Hair texture
  • Male pattern baldness
  • Probability of having red hair

Skin

  • Acne vulgaris
  • Skin melanin levels
  • Facial aging

Body structure and features

  • Height
  • Birth weight
  • Nasion prominence
  • Ear lobe type
  • Left-handedness

Eye features

  • Eye clarity
  • Pigmented rings on the iris

Smell, taste and reflex

  • Asparagus odour detection
  • Sense of smell
  • Photic sneeze reflex
  • Earwax type and armpit odour

Cognitive and behavioural

  • Cognitive ability
  • Mental agility
  • Neuroticism
  • Risk tendency

Ancestry

Origins and lineage

  • Biogeographical ancestry across global reference populations
  • Paternal haplogroup assignment
  • Maternal haplogroup assignment
  • Proportion of Neanderthal-derived DNA
  • How ancestry is distributed across populations